【摘要】 目的探讨基质金属蛋白酶(MMP-2、MMP-9)及其抑制剂(TIMP-1、TIMP-2)和细胞粘附分子CD15在肺癌浸润和转移中的作用,是否能为临床肺癌的诊断和治疗提供一种新的、有效的手段。方法通过免疫组化方法检测47例肺癌标本中MMP-2、MMP-9、TIMP-1、TIMP-2和CD15的表达情况。结果腺癌中MMP-2、TIMP-1阳性表达率明显高于鳞癌(P<0.01),鳞癌中MMP-9的阳性表达率高于腺癌(P<0.01);低分化者MMP-9的阳性表达率高于高、中分化者(P<0.05);有淋巴结转移者MMP-2、MMP-9和CD15的阳性表达率高于无淋巴结转移者(P<0.01);无淋巴结转移者中TIMP-1的阳性表达率高于有淋巴结转移者。结论肺癌组织中MMP-2、MMP-9、TIMP-1和CD15的阳性表达可能是肺癌恶性程度和预后判断的指标。更多还原

【Abstract】 Objective To evaluate the role of matrix metalloproteinases(MMP-2,MMP-9) and its inhibitors(TIMP-1,TIMP-2),and CD 15 antigen in the invasion and metastasis of lung cancer.Methods The expression of MMP-2,MMP-9,TIMP-1,TIMP-2 and CD15 were detected in 47 lung cancer tissues by immunohistochemical method.Results The positive rates of MMP-2,TIMP-1 in adenocarcinoma were remarkably higher than those in squamous cell carcinoma(P<0.01,(P<0.05),)the positive rates of MMP-9 in squamous cell carcinoma were remarkably higher than those in adenocarcinoma((P<0.01));The expression levels of MMP-9 in poor differentiated cancer were higher than those in well and medium differentiated cancer(P<0.05);The positive rates of MMP-2,MMP-9,and CD15 were higher in tumors with lymph node metastasis than those without lymphatic metastasis(P<0.01);The positive rates of TIMP-1 were higher in tumors without lymph node metastasis than those with lymphatic metastasis.Conclusion The expression of MMP-2,MMP-9,TIMP-1,and CD15 in lung cancer tissues might be a reference index in the malignant level and prognosis of lung cancer更多还原