【摘要】 目的探讨慢性乙型肝炎合并非酒精性脂肪性肝病(NAFLD)患者的临床和病理特征。方法对75例慢性乙型肝炎合并NAFLD患者进行肝穿刺组织活检和肝脏CT平扫,同时检测血液生化学指标,并与75例慢性乙型肝炎和41例NAFLD比较。结果慢性乙型肝炎合并NAFLD患者血清ALT、AST和GGT水平较慢性乙型肝炎和NAFLD患者明显增高(P<0.05,P<0.01);血清TC、TG、FBS、INS和IR I水平较单纯慢性乙型肝炎患者明显升高(P<0.05,P<0.01),而与NAFLD比较差异无统计学意义(P>0.05);脂肪变程度与慢性乙型肝炎组及NAFLD患者比较差异无统计学意义(P>0.05),而炎症计分和纤维化计分则明显升高,差异有统计学意义(P<0.05);肝/脾CT比值较慢性乙型肝炎降低(P<0.05),而较NAFLD患者高(P<0.05)。结论慢性乙型肝炎合并NAFLD患者的临床和病理特征不同于单纯的慢性乙型肝炎和非酒精性脂肪性肝病,NAFLD对慢性乙型肝炎进展有协同作用。更多还原

【Abstract】 Objective To investigate the character of clinic and pathology on patients with chronic hepatitis B(CHB) overlapped nonalcoholic fatty liver disease(NAFLD).Methods 75 patients with CHB overlapped NAFLD were done in liver by biopsy,and were checked the content of serum biochemistry,comparing with patients suffering from CHB or NAFLD.Results In this patients with CHB overlapped NAFLD,plasma ALT、AST、GGT concentrations were higher than that in CHB and NAFLD groups(P<0.05,P<0.01).Compared with CHB group,the levels of serum TC、TG、FBS、INS and IRI on patients with CHB overlapped NAFLD were increased(P<0.05,P<0.01)while liver/spleen CT ratio was reduced.In addition,the histopathological showed increased liver inflammation and fibrosis(P<0.05).Conclusion The character of clinic and pathology on patients with CHB overlapped NAFLD were different from those of CHB or NAFLD.更多还原