【摘要】 目的:探讨间变性大细胞微绒毛淋巴瘤的超微结构特点及鉴别诊断。方法:结合光镜、免疫组化及临床资料,对2例间变性大细胞微绒毛淋巴瘤进行超微结构观察。结果:光镜下,肿瘤呈窦性、巢团状浸润生长,瘤细胞排列紧密,体积大,核仁清楚。免疫组化显示瘤细胞CD30、EMA阳性。电镜下,瘤细胞表面有大量长短不一,粗细不等的微绒毛。胞质内有少量线粒体、核糖体、粗面内质网及高尔基复合体,1例偶见溶酶体样颗粒。核不规则,核仁明显,无细胞连接、基底膜及黑色素小体。结论:间变性大细胞微绒毛淋巴瘤的超微结构特征易与转移性低分化腺癌、恶性间皮瘤、黑色素瘤及毛细胞白血病鉴别。更多还原

【Abstract】 Objective:To investigate the character ultrastructural features of anaplastic large cell microvillous lymphoma(ALCML) and its differential diagnosis. Methods: Two cases speciments of ALCML were treated with routine LM and TEM procedures,immunohisochemical staining,and examined by light and electron microscope.Results:Microscopically,tumor cells showed the features of sinus-and nests-infiltration.Immunohistochemically,tumor cells showed positive expression for CD30 and EMA.Ultrastructurally,numerous cytoplasmic microvilli were seen on the tumor cell surface.No intercellular junctions or basal laminas were identified.In the cytoplasm,a few mitochondria,RER,free ribosome,well developed Gorgi complex and occasionally lysosome were seen.Conclusion: The ultrastructural features of ALCML can be differentiated from poorly differentiated adenocarcinoma,malignant mesothelioma,malignant melanoma and hairy cell leukemia.更多还原