【摘要】 用150只清洁级昆明系健康小鼠,进行“头孢沙星”原药1、0 g/L制剂口服及腹腔注射急性毒性试验。结果表明,其原药LD0在10 g/kg~15 g/kg之间,LD100大于15 g/kg;其10 g/L制剂LD50=527.38 mg/kg,95%可信限范围391.84 mg/kg~696.44 mg/kg。“头孢沙星”原药属于实际无毒,10 g/L制剂按2 mg/kg临床应用安全。更多还原

【Abstract】 The acute toxicity tests of "Toubaoshaxing" and 10 g/L preparation were carried out in 150 mice.The results showed that"TouBaoShaXing"maximal tolerance dose(LD₀)varied from 10 g/kg to 15 g/kg,and absolute lethal dose(LD₁₀₀)>15 g/kg.Median lethal dose(LD₅₀)of 10 g/L preparation was（527.38 mg/kg.）The 95% certainty factor varied from 391.84 mg/kg to 696.44 mg/kg.Such a conclusion can be obtained that"Toubaoshaxing" is nontoxicity and 2 mg/kg dose of 10 g/L preparation is clinical safe.更多还原