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四甲基哌啶酮对小鼠的急性和慢性毒性试验
Experiment of Acute and Chronic Toxicities of TMPD in Mice
【摘要】 为了探讨小鼠长期接触2,2,6,6-四甲基哌啶酮(TMPD)引起有害效应的剂量,以评价对其进行长期接触的危险性,对小鼠进行TMPD的急性和亚慢性毒性试验。结果表明,TMPD对小鼠具有一定急性毒性(LD50=292.429mg/kg-1);亚慢性毒性表现出一定的雌雄差异,肝脏和肾脏是其主要靶器官。
【Abstract】 To Find out the dose which is harmful with a long period contact and evaluate the contacting danger of 2,2,6,6-Tetramethyl-4-Piperidone(TMPD) to mice in vivo. Research the acute and chronic toxicity of TMPD to mice. The results suggested thatTMPD has acute toxicity on mice (LD50=292.429 mg/kg);sexual difference exist in chronic toxicity, liver and kidney are the main target organs.
【关键词】 2,2,6,6-四甲基哌啶酮;
慢性毒性;
小鼠;
牛心朴子;
【Key words】 2,2,6,6-Tetramethyl-4-Piperidone (TMPD); Chronic toxicity; mice; Cynanchum Komanovii AL Iljinshi;
【Key words】 2,2,6,6-Tetramethyl-4-Piperidone (TMPD); Chronic toxicity; mice; Cynanchum Komanovii AL Iljinshi;
- 【文献出处】 动物医学进展 ,Progress in Veterinary Medicine , 编辑部邮箱 ,2006年01期
- 【分类号】S859.82
- 【被引频次】3
- 【下载频次】223