【摘要】 目的比较犬颈总动脉和股静脉持续输注异丙酚至脑电静息时循环、呼吸变化及异丙酚的用量。方法杂种犬8条,通过颈总动脉或股静脉持续输注异丙酚直至麻醉深度指数(CSI)等于零,并维持CSI在0-5之间波动持续60min停药。记录意识消失、恢复时间及异丙酚用量,观察犬血流动力学和呼吸的变化。结果达脑电静息所用时间和停药后苏醒时间,颈总动脉给药明显快于静脉给药(P<0.05)。颈总动脉和股静脉给药在意识消失时、CSI=0-5持续10s、30min和60min时异丙酚的用量分别为(76.1±24.3)mg和(146.9±48.3)mg(P=0.000)、(221.3±47.4)mg和(353.3±89.2)mg(P=0.000)、(474.9±122.5)mg和(845.8±206.8)mg(P=0.000)以及(721.3±204.0)mg和(1401.4±410.4)mg(P=0.000)。在脑电静息各时点,颈总动脉给药对平均动脉压和呼吸的影响与静脉给药比较统计学差异非常显著,动脉给药血流动力学和呼吸指标变化更平稳。结论异丙酚颈动脉麻醉至脑电静息比静脉麻醉用药量少,对循环、呼吸影响小。更多还原

【Abstract】 Objective To compare the effects of common carotid artery and femoral vein administration of propofol for electrocerebral silence(ES)on circulatory and respiratory function and the dosage of propofol required during ES in dogs.Methods Eight dogs were anesthetized by common carotid arterial and femoral vein administration of propofol for ES for 1 h.The time of consciousness loss and recovery,dose of propofol during ES,mean arterial pressure,heart rate,respiration rate,end-tidal carbon dioxide,SpO2,cerebral state index(CSI)and anal temperature were continuously monitored.Changes in the outcome variables were analyzed at 7 time points,namely the baseline,upon loss of consciousness,at 10 s,30 min and 1 h of CSI=0,and recovery of CSI and consciousness.Results Carotid artery propofol administration produced ES with only half of the dose for intravenous administration.Compared with the baseline values,the mean artery pressure and respiration rate remained unchanged or decreased transiently during ES with carotid artery propofol administration.In contrast,intravenous propofol administration resulted in systemic hypotension and severe respiratory depression.Conclusion Carotid artery propofol administration produces ES with a much smaller dose than intravenous propofol administration without causing systemic hypotension or respiratory depression.更多还原