【摘要】 目的研究血清甲状腺素结合能力对游离甲状腺素免疫测定法检测偏差的影响。方法以平衡透析法为基准,以16位孕期超过6个月的孕妇和32位住院患者为对象,研究免疫测定法的检测偏差。结果16位孕期超过6个月的孕妇具有高血清甲状腺素结合能力,15位住院患者具有正常血清甲状腺素结合能力,另外17位住院患者具有低血清甲状腺素结合能力。对于正常血清甲状腺素结合能力组和高血清甲状腺素结合能力组,各种免疫测定法与平衡透析法的检测结果之间不存在显著性差异(P>0.05或P>0.01)。对于低血清甲状腺素结合能力组各种免疫测定法与平衡透析法的检测结果之间存在显著性差异(P<0.01)。平均偏差均为负值。结论血清甲状腺素结合能力影响游离甲状腺素免疫测定法的检测偏差。更多还原

【Abstract】 Objective To study the effects of the serum thyroxine-binding capacity on the biases in free thyroxine immunoassays.Methods Based on direct equilibrium free ftyroxine assay,16 women in the last 3 months of pregnancy and 32 in patients as subjects,to probe biases of immunoassays.Results The women in the last 3 months of pregnancy was classified into the high serum thyroxine-binding capacity group,15 in patients into the nomal serum thyroxine-binding capacity group,and another 17 in patients into the low serum thyroxine-binding capacity group.No significant bias was found between the investigated immunoassays and the direct equilibrium free thyroxine assay in the high serum thyroxine-binding capacity group and the normal serum thyroxine-binding capacity group(P>0.05 or P>0.01).In the low serum thyroxine-binding capacity group,all investigated immunoassays showed a significant(P<0.01)and marked negative bias.Conclusions The investigated free thyroxine immunoassays showed serum thyroxine-binding capacity dependent biases.更多还原