【摘要】 目的:研究胃癌患者癌组织中EB病毒(EBV)感染与CyclinD1表达的关系.方法:原位杂交法检测胃癌患者石蜡标本中EBV编码的小RNA(EBER1);免疫组化法检测EBV阳性胃癌[EBV(+)]及EBV阴性胃癌[EBV(-)]标本细胞周期蛋白Cyclin D1的表达状况.结果:胃癌患者癌组织标本217例中23例EBER1(+);EBV(+)组Cyclin D1蛋白表达显著高于EBV(-)组(P<0.01).结论:EBV感染可能上调CyclinD1表达.更多还原

【Abstract】 AIM:To investigate the relativity between the Epstein- Barr Virus （EBV） infection and the expression of Cyclin D1 in gastric carcinoma （GC） patients. METHODS: EBER₁ in 217 cases of GC was detected with in situ hybridization. Then, EBV positive and negative GC cases were selected for analysis of the expression of Cyclin D1 by immunohistochemistry. RESULTS: In 217 GC cases there were 23 cases with EBER₁ positive expression. The expression of Cyclin D1 was higher in the EBV positive GC than that in the EBV negative （P<0.01）. CONCLUSION: EBV infection in GC may upregulate the expression of Cyclin D1.更多还原