【摘要】 目的研究中药复方制剂利脑宁(LNN)的镇静催眠作用,为该药的临床应用提供实验依据.方法采用小鼠自发活动、戊巴比妥钠睡眠时间的研究方法,进行镇静催眠实验.结果LNN可显著减少小鼠的走动时间和小鼠双前肢的抬举次数,与给药前比较,LNN低剂量组(P<0.05),中、高剂量组(P<0.01),亦能明显延长小鼠戊巴比妥钠的睡眠时间,与对照组比较,具有显著性差异(P<0.05,P<0.01),该作用呈剂量依赖性.结论利脑宁具有镇静催眠作用.更多还原

【Abstract】 AIM: To study the sedative-hypnotic effect of Linaoning (LNN) (a complex prescription of traditional Chinese medicine ), and provide an experimental base and a theoretical foundation for its clinical application. METHODS: The sedative-hypnotic effect was studied by observing the spontaneous action and pentobarbital sleeping time in mice. RESULTS: LNN obviously decreased the walking time and the frequence of its raising forelimb. Compared with pre-administration or control group, low-dose LNN (P<0.05), middle and high-dose-LNN (P< 0.01) obviously prolonged the pentobarbital sleeping time in mice in a dose-dependent manner. CONCLUSION: LNN does have the sedative -hypnotic effect.更多还原