【摘要】 目的:了解前列腺素E1(PGE1)对糖尿病肾病(DN)患者肾动脉血流动力学的影响.方法:利用彩色多普勒观察95例DN患者经PGE1治疗前后的肾动脉血流动力学的变化.结果:DN患者肾动脉血流动力学的各项参数,特别是肾动脉内径、时间速度积分、阻力指数变化显著(P<0.01);PGE1治疗后,其各项参数均有明显的变化(P<0.05);同时BUN,Cr水平由治疗前的(10.1±5.4)mmol/L,(194±51)μmol/L降至(7.9±6.0)mmol/L,(99±35)μmol/L,尿量由(948±128)mL/d增至(1242±373)mL/d,均有明显的改善(P<0.05).结论:DN时多伴有凝血、纤溶障碍所导致的肾动脉血流动力学的变化,应用PGE1治疗有益于延缓肾功能的恶化.更多还原

【Abstract】 AIM: To observe the effect of prostaglandin-E₁ （PGE₁） on the hemodynamics of renal arterial blood flow in diabetic nephropathy （DN）. METHODS: The renal color Doppler ultrasound was employed to examine renal arterial blood flow before and after treatment with PGE₁ in 95 DN patients and 88 normal controls. RESULTS: The hemodynamic parameters of renal arterial blood flow in DN patients, especially the inner diameter of renal artery, velocity time integral and resistent index, were significantly changed （P<0.01）; after treatment with PGE₁ the parameters mentioned above were changed as well （P<0.05）;the levels of BUN and Cr increased from （10.1± 5.4） mmol/L,（194±51） μmol/L before treatment to （7.9± 6.0） mmol/L,（99±35） μmol/L after treatment, and the amount of urine increased from （948±128） mL/d to （1242±373） mL/d; the parameters of renal function were improved significantly（P<0.05）. CONCLUSION: The hemodynamics of renal arterial blood flow in DN patient was changed, which was caused by the coagulation disorders and fibrinolytic disorders. The application of PGE₁ in the treatment of renal failure is beneficial to delay the deterioration of renal function.更多还原