【摘要】 目的探讨幽门螺杆菌感染和不孕不育症的关系及其可能的免疫学因素.方法用ELISA法检测不孕症(n=67),不育症(n=58)患者血清抗H.pylori-IgG,抗精子抗体,T细胞亚群及部分细胞因子水平.结果不孕不育症患者血清H.pylori-IgG和AsAb依次为46.4%和21.6%,与对照组相比差异均具有显著性(P<0.01).抗H.pylori-IgG阳性和阴性的患者AsAb阳性率依次为32.8%和11.9%(P<0.01).血清抗H.pylori-IgG阳性的患者外周血CD3+,CD4+,CD4+/CD8+均下降,血清IL-4,IL-6,IFN-γ,TNF水平均上升,IFN-γ/IL-4比值下降(P<0.05).结论H.pylori是引起不孕不育的病原体之一,抗精子抗体和细胞因子水平升高,可能参与不孕症的发生发展.更多还原

【Abstract】 AIM: To study the relationship between Helicobacter pylori infection and infertility. METHODS: Serum H.pylori-IgG, antisperm antibody (AsAb), T lymphocyte subsets and some cytokines were detected in 125 patients (male 58, femal 67) with infertility. RESULTS: The positive rates of H.pylori-IgG and AsAb in patients with infertility were 46.4% and 21.6%, which were higher than those in normal control group (P<0.01). The positive rates of AsAb in patients with H.pylori-IgG-positive or-negative infertility patients were 32.8% and 11.9%, with a significant difference between them (P<0.01). In H.pylori-IgG-positive infertility patients, the CD3+, CD4+ and CD4+/CD8+ decreased, the serum IL-4, IL-6, IFN-γ and TNF increased, and the ratios of IFN-γ to IL-4 decreased (P< 0.05). CONCLUSION: H.pylori is an infertility-causing pathogen. The increased positive rates of AsAb and cytokines may be involved in the development of infertility.更多还原