【摘要】 目的了解儿童紫癜性肾炎临床特点及血浆内皮素-1变化的临床意义。方法总结2000年1月至2005年6月84例紫癜性肾炎(HSPN)患儿的临床资料,对HSPN发生的流行病学、临床、病理特征进行分析。采用同位素放免法对84例HSPN患儿及16例正常儿童进行血浆内皮素-1(ET-1)浓度检测。结果①发病年龄在5~10岁者占90.6%,9月至次年3月为高发病期,发病率占80.32%;感染仍是主要诱因(40.57%);胃肠症状首发时33.33%发生误诊。临床上以肾病综合征表现最常见(47.63%)。病理分型以Ⅱ级最多见(37.84%),Ⅲ级以上占56.40%。2、HSPN患儿血浆ET-1水平明显高于正常对照组。其血浆ET-1水平与血尿素氮、肌酐呈正相关(r=0.584,0.523,P<0.05)。结论HSPN的发病具有一定的流行病学特征。HSPN患儿血浆ET-1水平升高与肾功能损害有关。更多还原

【Abstract】 Objective To investigate the clinical features of Henoch-Schonlein purpura nephritis(HSPN) and the clinical significance of plasma endothelin-1(ET-1) in HSPN.Methods The epidemiology and clinical characteristics were retrospectively analyzed in 84 patients admitted to our hospital from January 2000 to March 2005.The changes of ET-1 were measured in 84 patients and 16 controls by using radioimmunologic assay.Results The age of onset in HSPN was 5-10 years and the corresponding patients occupied 90.6%.The majority of HSPN cases(80.32%) occurred from September to March of the second year.Infection was still the main occasion factor(40.57%),and the mistaken diagnosis at rate of 33.33% as acute gastricism and appendicitis when gastrointestinal sign appeared earlier than the typical purpura.The nephritic syndrome was the most constant clinical manifestation(47.63%).The pathological type of grade Ⅱ was 37.84%,grade Ⅲ 56.40%.The level of plasma ET-1 in patients was more higher than that of normal controls.The level of plasma ET-1 had a positive correlation with plasma urea nitrogen and creatinine(r=0.584,0.523,P<0.05).Conclusion HSPN was of definite epidemiological features.The level of ET-1 was correlated with the lesion of renal function.更多还原