【摘要】 [目的]观察裙带菜多糖的体内、外抗肿瘤作用,并对其机制进行讨论。[方法]采用MTT法观察裙带菜多糖体外对人肝癌细胞HepG-2的抑制作用;通过对615荷瘤小鼠瘤重及免疫器官脾脏的研究,观察了裙带菜多糖的体内抗肿瘤作用。[结果]与阴性对照组相比裙带菜多糖各浓度组体外对人肝癌细胞HepG-2均有很强的抑制作用(P<0.01),其中15、10 mg/mL组的抑制率分别为57.20%、51.79%,略低于5-FU组;在荷瘤小鼠实验中,与空白对照组相比裙带菜多糖各浓度组均有很强的肿瘤抑制作用,其中400、200 mg/kg组抑瘤率分别为69.13%、42.11%,与5-FU组相近。[结论]裙带菜多糖对人肝癌细胞HepG-2抑制效果显著,小鼠体内实验也证实了裙带菜多糖较强的抗肿瘤作用。更多还原

【Abstract】 [Objective] To investigate the anti-tumor effect of polysaccharides from the Undaria Pinnatifida on tumor cell strain and Hca-f mice and the mechanism of anti-tumor activities was discussed at the same time.[Methods] MTT were applied to study the anti-tumor activities of UPPS to HepG-2 cell strain in vitro;The anti-tumor activities were observed in vivo by testing the tumor weight and the weight of spleen of Hca-f mice.[Results] The anti-tumor activities of UPPS to HepG-2 cell strain in vitro were significantly higher than the negative control group(P<0.01)and 15、10 mg/mL of UPPS inhibiting rate were 57.20%,(51.79%,)which were similar to 5-FU.The anti-tumor activities of UPPS in vivo were significantly higher than the negative control group and 400,200 mg/kg of UPPS inhibiting rate to Hca-f mice were 69.13%,42.11%,which were similar to 5-FU and showed potent anti-tumor activities.[Conclusions] UPPS show potent anti-tumor activities to HepG-2 cell strain and Hca-f mice.更多还原