【摘要】 目的:用动态血压监测(ABPM)方法进行厄贝沙坦和比索洛尔对比研究来评价厄贝沙坦治疗轻、中度高血压的有效性及安全性。方法:62例轻、中度高血压患者随机分为2组,分别服用厄贝沙坦150-300mg和比索洛尔5-10mg,每日 1次,在治疗前后8周采用24小时ABPM评价降压效果。结果:治疗后两组病人的血压均有明显下降,厄贝沙坦组24h平均收缩压(SBP)由治疗前(147．3±9．4)mmHg降至(132．2±10．6)mmHg,舒张压(DBP)由治疗前(94．7±7．5)mmHg降至治疗后(83．2±9．7)mmHg,SBP、DBP谷／峰比值分别为分别69％、72％,比索洛尔组24h平均SBP由治疗前(146．8±9．2) mmHg降至(133．4±10．3)mmHg,DBP由治疗前(94．4±6．8)mmHg降至治疗后(84．5±10．5)mmHg,SBP、DBP谷／峰比值分别为65％、68％。两组均有较好的降压效果,血压较治疗前明显降低(P<0．01),但两组间血压下降差别无统计学意义 (P>0．05)。8周末厄贝沙坦组总有效率为77％,比索洛尔组为74％。不良反应发生率两组间比较无显著性差异(P> 0．05)。结论:厄贝沙坦150-300mg,每日1次,对轻、中度高血压病疗效确切,可维持24小时的降压作用。更多还原

【Abstract】 Objective:To evaluate the efficacy and safety between irbesartan and bisoprolol in the patients with mild - to - moderate essential hypertension by ABPM(ambulatory blood pressure monitoring) .Methods: 62 patients with essential hypertension were randomized two group, 31 cases to irbesartan treatment group(irbesartan 150-300mg/d) and 31 cases to bisoprolol treatment group (bisoprolol 5-10mg/d) after a 2-week washout period.24h blood pressure monitoring was carried out by ABPM following 8 week’ s treatment.Results: After treatment blood pressure significantly decreased in both groups.SBP decreased from(147.3±9.4)mmHg to (132.2±10.6) mmHg,DBP decreased from (94.7±7.5) mmHg to(83.2±9.7) mmHg, T/P of SBP and DBP was 69% and 72% in irbesartan group,SBP decreased from (146.8±9.2) mmHg to (133.4±10.3) mmHg, DBP decreased from (94.4±6.8) mmHg to (84.5±10.5)mmHg,T/P of SBP and DBP was 65% and 68% in bisoprolol.(compared with before treatment P<0.01). No significantly difference between two groups for blood pressure (P>0.05).At 8-week,the total efficacy rate in ibesartan group was 77% and in bisoprolol group was 74% ,respectively(P >0.05) .The adverse events were no significant between the two treatment groups(P>0.05).Conclusion:Irbesartan was effective in patients with mild - to - moderate essential hypertension and prduce sustained 24h blood pressure control.更多还原