【摘要】 目的探讨幽门螺杆菌(Hp)血清CagA抗体与胃癌和非胃癌消化系统恶性肿瘤的关系。方法以结直肠癌和肝胆胰癌为非胃癌对照组,检测胃癌患者血清抗-Hp-CagA-IgG和抗-Hp-IgG,并分析它们与胃癌和对照组的关系。结果胃癌组患者共50例,结直肠癌和肝胆胰癌各35例(非胃癌组70例),它们的年龄(F=0.01,P>0.1)和性别(χ2=1.65,P>0.1)组成具有可比性;CagA抗体(+)率胃癌(58.0%)比非胃癌组(28.6%)高(χ2=10.46,P<0.01),OR(优势比)=3.45(95%C I 1.61~7.42);抗-Hp-IgG(+)率胃癌(68.0%)比非胃癌组(35.7%)高(χ2=12.16,P<0.01),OR=3.83(95%C I 1.77~8.23);结直肠癌和肝胆胰癌间CagA抗体(+)率(34.3%vs 22.9%,χ2=1.12,P>0.1)和抗-Hp-IgG(+)率(34.3%vs 37.1%,χ2=0.06,P>0.1)相当。结论血清Hp抗体与胃癌关系极为密切,抗-Hp-IgG和CagA抗体对胃癌具有同样的预示性;CagA抗体和抗-Hp-IgG阳性者检出胃癌的危险性分别是非胃癌消化系统恶性肿瘤的3.5倍和3.8倍。更多还原

【Abstract】 Objective To investigate relationship between anti-CagA of helicobacter pylori(H.pylori) and gastric cancer(GC) and non-gastric gastrointestinal malignant tumor(NG-GMT).Methods The indexes such as anti-H.pylori-CagA-IgG and anti-H.pylori-IgG were measured in 50 GC patients and 70 NG-GMT control patients including 35 cases with colorectal cancer(CRC) and 35 with hepato-bilio-pancreatic cancer(HBPC).Results The age and sex configuration of the patients involved in the study had no significant difference(F=0.01,P>0.1 and χ~2=1.65,P>0.1).The positive rates of anti-CagA were 58.0%(29/50) in GC and 28.6%(20/70) in NG-GMT(χ~2=10.46,P<0.01),the odds ratio(OR) of which was 3.45 [95% confidence interval(CI) 1.61 to 7.42].The positive rates of anti-H.pylori-IgG were 68.0%(34/50) in GC and 35.7%(25/70) in NG-GMT(χ~2=12.16,P<0.01),the OR of which was 3.83(95%CI 1.77 to 8.23).The positive rates of anti-CagA in CRC and HBPC(34.3% vs 22.9% respectively,χ~2=1.12,P>0.1) and those of anti-H.pylori-IgG(34.3% vs 37.1% respectively,χ~2=0.06,P>0.1) were not significantly different.Conclusion The seropositivity of H.pylori,anti-CagA and anti-H.pylori-IgG are associated with the risk of gastric cancer.更多还原