【摘要】 目的揭示血清白细胞介素6(IL-6)水平在脓毒症患者体内变化规律及意义。方法分别抽取40例APACHEⅡ评分>12分的脓毒症患者和30例正常人的外周血,应用放射免疫分析法检测其血清IL-6水平。将这2组血清IL-6水平进行比较。同时将脓毒症组的IL-6水平与病人的预后、APACHEⅡ评分作相关性分析。结果脓毒症组血清IL-6水平[(152.02±55.77)pg/m l],与正常对照组IL-6[(85.79±30.96)pg/m l]比较差异有统计学意义(P<0.01)。脓毒症组血清IL-6水平与病人的预后呈正相关(r=0.667,P=0.000),与APACHEⅡ评分呈正相关(r=0.485,P=0.002)。40例感染患者中有20例死亡,他们的血清IL-6水平[(186.20±48.74)pg/m l]较生存病例[(117.84±39.36)pg/m l]高(t=4.880,P=0.000)。结论脓毒症时,血清IL-6水平升高,其升高反应了感染的严重程度,与预后有较好的相关性。更多还原

【Abstract】 Objective To investigate the regularity and significance of serum interleukin-6(IL-6) levels in the patients with sepsis.Methods Forty sepsis patients with APACHEⅡ scores over 12 and 30 normal controls were involved in the study.The IL-6 levels in serum were detected with radio-immunity analysis assay and the correlations among the IL-6 levels,the prognosis and APACHEⅡ score were investigated.Results In the patients with sepsis,the average level of IL-6 in serum was(152.02±55.77) pg/ml,which was significantly higher than that of the control group [(85.79±30.96) pg/ml](P<0.01).In the patients with sepsis,there was a positive correlation between the IL-6 levels and the prognosis(r=0.667,P=0.000),and the IL-6 levels were positively correlated with the APACHEⅡ score(r=0.485,P=0.002).Among 40 patients with sepsis,20 patients were dead and the IL-6 level in the 20 patients [(186.20±48.74) pg/ml] were higher than that of the survivors [(117.84±39.36) pg/ml](t=4.880,P=0.000).Conclusion The IL-6 levels are increased in the serum of the patients with sepsis and there is a positive correlation between the IL-6 levels and prognosis.更多还原