【摘要】 目的分析子宫内膜癌HLA-DR表达及癌组织中树突细胞(DC)的密度,探讨两者对子宫内膜癌患者临床分期及预后的影响。方法86例子宫内膜癌石蜡标本,应用免疫组织化学SP法检测癌组织HLA-DR表达和S100阳性树突细胞的浸润密度,并与患者的临床分期和预后进行统计学分析。结果子宫内膜癌HLA-DR表达率27.9%(24/86),表达率随临床分期增加而逐渐下降(P<0.05),但对预后无明显影响(P>0.05)。S100阳性DC丰富(≥10/HPF)的病例为46.5%(40/86),DC浸润密度在患者的临床分期和预后方面差异均有统计学意义(均为P<0.05)。HLA-DR表达与DC浸润程度密切相关(r=0.522;P<0.01)。结论HLA-DR表达与DC浸润密度可能反映了子宫内膜癌患者的抗肿瘤免疫状况,可能成为判断临床分期和预后的重要指标。更多还原

【Abstract】 Objective To investigate the expression of HLA-DR and distribution of dendritic cells(DC) in endometrial carcinoma and to evaluate their influence on clinical staging and prognosis.Methods The 86 cases of patients with endometrial carcinomas were detected by immunohistochemical SP method for HLA-DR and S100 positive dendritic cells,and the predictive value in clinical stage and prognosis were analyzed.Results The positive rate of HLA-DR expression was 27.9%(24/86),which was decreased with the increase of clinical staging(P<0.05),and was not significantly related with the prognosis(P>0.05).There were 46.5%(40/86) of the cases with a dense infiltrate(≥10/HPF) of S100 positive DC.There was significant difference on the density of DC infiltrating among the patients with different clinical stages and prognosis(all P<0.05).The HLA-DR expression was closely correlated with DC infiltrate(r=0.522;P<0.01). Conclusion The expression of HLA-DR and infiltrate of dendritic cells may reflect the anti-tumor immunity of patients with endometrial carcinoma and may be served as the predictive factors of clinical stage and prognosis.更多还原