【摘要】 目的:通过研究CD44v6在卵巢上皮性肿瘤中的表达,探讨该指标与卵巢癌淋巴结转移的关系。方法:用免疫组化ElivisionTM法检测80例卵巢上皮性肿瘤中CD44v6的表达;运用图像分析系统对该指标进行定量检测。结果:①定性及半定量结果:CD44v6的表达呈递增趋势,组间有显著差异(P<0.05);②定量检测结果:CD44v6的表达,面积呈递增趋势,灰度呈递减趋势。结论:CD44v6表达升高,提示肿瘤进展,恶性度高,预后不良;计算机图像分析系统对卵巢上皮性肿瘤的自动化诊断、淋巴结转移及预后评估有重要意义。更多还原

【Abstract】 Objective:Through the investigating the molecular expressions of CD 44v₆ in ovarian epithelial neoplasms, this study is trying to explore the relationship between the lymphatic spread of the tumor with the molecule. Methods: 80 cases were examined through Elivision TM, an immune histochemistry method, for the expression of CD 44v₆ in ovarian epithelial neoplasms. The system of image analysis was used to measure the expression of various molecules quantitatively. Results: ①Qualitative and semi-quantitative results:the expression of CD 44v₆ has upward tendency in that order and there is significant difference on the expression levels of CD 44v₆ （P<0.05）.②Quantitative examination result: The total positive cell area of CD 44v₆ expression in the tumor has upward tendency in the order of benign, boundary and malignant cases, and the gray degree has downward tendency. Conclusion: Uprising expression of CD 44v₆ suggest the rapid development, high degree of malignancy and poor prognosis; The study also shows the improtance of using the computer image analysis for automatic diagnosis of the ovarian epithelial neoplasms,lymphatic metastases and its prognostic estimation.更多还原