【摘要】 目的探讨甲状腺动脉栓塞术治疗Graves病的疗效及中、远期临床疗效的影响因素。方法对37例 Graves病行动脉栓塞治疗的病人进行中、远期随访;对所有患者术前自身免疫状态、甲状腺激素水平、复发的时间、栓塞血管数量及栓塞剂选择等因素对临床疗效的影响进行分析。结果 37例患者中,29例患者栓塞后症状、体征消失或明显改善,血清甲状腺素水平恢复正常或明显下降。21例治愈,8例好转,6例复发,1例无效,发生脑梗塞并发甲亢危象死亡1例。结论 Graves病动脉栓塞治疗近期效果良好,疗效与栓塞血管支数、术前甲状腺激素水平及术中PVA联合使用罂粟碱及平阳霉素等因素有关。更多还原

【Abstract】 Objective To investigate factors which affect the mid - or long - term clinical effect of thyroid arterial embolisation to treat Graves disease. Methods Thirty - seven patients of Graves disease had been followed up mid - or long - term. Multiple factors which may affect the clinical effect were analysed such as the immune state and the blood thyroid hormone level before embolisation, the time of hyperthyroidism recurrence, the number of thyroid arteries embolised and the choice of embolism agents. Results Twenty - nine patients’ symptoms and signs of hyperthyroidism disappeared or were improved greatly with 21 cured and 8 improved. Six cases were recurrent and one had brain infarction and died because of hyperthyroidism crisis. Conclusion The thyroid arterial embolisation has clinical effect on all the patients by short - term. The clinical effect of embolising is correlation to the number embolising arteries, the thyroid hormone level and the combined use of papaverine and pingyangmycin.更多还原