【摘要】 树突细胞是一类复杂的、具有异质性、可塑性的细胞,是“专职的”抗原呈递细胞,也是体内唯一可激活“初始型”免疫反应的细胞,它参与了机体免疫应答或免疫耐受的全过程。近年来,树突细胞在机体免疫系统中的重要作用日益引起人们的重视,在移植排斥反应、肿瘤免疫治疗、感染性疾病和自身免疫性疾病等的诊治方面均有研究报道,同时人们对树突细胞的生物学特性、与某些疾病的发生、预后等关系也有进一步深入的研究。作者就近年来树突细胞对免疫调节功能的研究及应用进行综述。更多还原

【Abstract】 Dendritic cells(DCs),representing a heterogenous population of professional antigen-presenting cells,is the initiator and modulator of the immune response.Cells of dendritic family not only control immunity but also maintain tolerance to self-antigen.Therefore,DCs may be valuable tools for modulating immunity in the setting of auto-immunity,cancer,chronic viral infections and graft rejection,etc.Here we discuss the current knowledge on the function of denditic cells-based immunoregulation and therapeutic applications.更多还原