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血管紧张素转换酶基因DD基因型与脑出血的相关性研究

Study on the relativity between DD genotype of angiotensin converting enzyme gene and cerebral hemorrhage

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【作者】 蔡坤皓戴黎萌陈东赵永阳

【Author】 CAI Kun-hao DAI Li-meng CHEN Dong ZHAO Yong-yang. Department of Neurosurgery,Shenzhen People’s Hospital,Second Affiliated Hospital,Ji’nan University Medical College,Shenzhen 518020,China

【机构】 暨南大学附二院深圳市人民医院神经外科暨南大学附二院深圳市人民医院神经外科

【摘要】 目的探讨血管紧张素转换酶(ACE)基因多态性分布与高血压脑出血发病的关系。方法应用聚合酶链反应方法检测200名健康人(NT)及80例高血压合并脑出血患者ACE I/D基因多态性。结果脑出血患者的DD基因型及D等位基因频率和正常对照组比较差异有显著意义(P<0.05)。结论ACE基因DD基因型和D等位基因携带者可能是高血压合并脑出血的易感因素。

【Abstract】 Objective To identify the I/D polymorphism of angiotensin coverting enzyme (ACE) in hypertension patient complicated with intracerebral hemorrhage.Methods ACE genotyping with polymerase chain reaction (PCR) were used to detect ACE gene I/D polymorphism in 200 normotensive controls and 80 hypertensive patients complicated with intracerebral hemorrhage.Results The frequencies of the ACE D allele in groups of hypertension complicated with intracerebral hemorrhage were higher than in the health controls (P<0.05).Conclusion ACE gene DD homozygosity of the I/D polymorphism in intron 16 is an independent risk factor for hypertension complicated with intracervral hemorrhage.

  • 【文献出处】 中华神经医学杂志 ,Chinese Journal of Neuromedicine , 编辑部邮箱 ,2006年08期
  • 【分类号】R743.34
  • 【被引频次】10
  • 【下载频次】103
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