【摘要】 目的研究碱性髓鞘蛋白(MBP)与脑出血破入脑室患者病情预后的关系。方法选取2002￣2005年我院脑出血破入脑室住院病人30例,分别于脑出血后12h和第3、7、21天采集外周静脉血进行MBP检测,根据患者脑出血后2个月格拉斯哥预后评分(GOS)分为预后不良组和预后良好组。体检正常者15例为正常对照组进行MBP检测。结果脑出血破入脑室患者出血后血清MBP浓度显著高于正常对照组,其浓度随时间的推移呈下降趋势,但仍高于正常对照组;预后不良组出血后MBP浓度在检测时间点持续高于预后良好组,且有统计学差异(P<0.01)。结论MBP的浓度与脑出血破入脑室患者的预后有一定的相关关系,MBP浓度越高,其预后越差。更多还原

【Abstract】 Objective To study the relationship between MBP and prognosis of the patients with intracerebral hemorrhage disrupting into intraventricular system. Methods 30 patients with intracerebral hemorrhage disrupting into intraventricle (2002~2005), whose MBP of venous blood were analyzed after hemorrhage 12 hours, 3 days, 7 days, and 21 days respectively, and were divided into excellent prognosis group and worse prognosis group according to Glasgow outcome scale(GOS) after 2 months hemorrhage. 15 normal persons consisted of a controlled group. All the databases were analyzed through SPSS 11.0. Results The serum MBP level in the patients of intracerebral hemorrhage disrupting into intraventricle increased significantly after hemorrhage and then decreased higher than that in the controlled group. The serum MBP level in the excellent prognosis group were much higher than that in the worse prognosis group at the corresponding time with significant difference (P<0.01). Conclusion The higher serum MBP level the patients with intracerebral hemorrhage disrupting into intraventricle have, the worse clinical outcome they could have.更多还原