【摘要】 目的:观察、比较不同产地荆芥挥发油的成分、药理作用的不同。方法:采用气质联用法进行挥发油化学成分分析;测定不同产地荆芥挥发油的半数致死量(LD50);二甲苯致小鼠耳廓肿胀试验观察不同产地荆芥挥发油的抗炎作用。结果:河北与湖南荆芥挥发油中薄荷酮和胡薄荷酮的比例分别为3.7∶1、1.1∶1;河北荆芥挥发油的LD50为(6.894±0.611)mL/kg,湖南样品为(0.842±0.092)mL/kg;河北样品0.4 mL/kg连续给药3天能显著对抗二甲苯所致小鼠耳廓肿胀,湖南样品同等剂量单次给药即表现出明显对抗作用。结论:不同产地荆芥挥发油中主要成分薄荷酮和胡薄荷酮比例的差异,可能造成其LD50、有效浓度及起效时间发生改变,但有待进一步探讨。更多还原

【Abstract】 Objective:Observe and compare the chemical components and pharmacology action of Sto（Schizonepetae Volatile oil） which from different place of produce.Methods:The chemical components of Sto were determined by GC-MS.Through determining the LD₅₀ to compare the toxicity of Sto which from different place of produce.Study the anti-inflammatory action of Sto by swelling of pinna induced by xylene in mice.Results: The ratio of menthol and pulegone in Sto that come from hebei and hunan was 3.7∶1、 1.1∶1 respectively.The LD₅₀ of Sto that from Hebei was（6.894±0.611）ml/kg,meanwhile Hunan was（0.842±0.092） ml/kg.The sample from Hebei（0.4）ml/kg was intragastricly administrated for 3 days,significantly suppressed the swelling of pinna induced by xylene in mice.Meanwhile acute administration ofthe sample from Hunan showed the anti-inflammatory action in the same model in mice.Conclusion: Different place of produce of Sto maybe contribute to the difference in the ratio and level of main components,toxicity and pharmacodynamic action.Furthermore advanced investigation is needed.更多还原