【摘要】 目的:探讨妊娠滋养细胞肿瘤(GTT)中的细胞凋亡情况。方法:采用核酸原位末端标记(TUNEL)法,检测10例正常早期绒毛(NP)、10例完全性葡萄胎(CM)、20例侵袭性葡萄胎(IM)、19例绒癌(CCA)中的细胞凋亡。结果:在NP、CM、IM和CCA中,细胞凋亡指数(AI)分别为1.88%、2.59%、6.45%、1.26%,各组间差异有统计学意义,(F=7.020,P=0.000)。其中,在IM与CCA之间,差异有统计学意义(P=0.009)。结论:GTT的发生是由于机体监控能力减弱或消失、增殖与凋亡调节系统失调所致。更多还原

【Abstract】 Objective:To investigate the apoptosis in gestational trophoblastic tumor(GTT).Methods:10 cases of normal placenta,10 cases of complete hydatidiform mole(CM),20 cases of invasive hydatidiform mole(IM) and 19 cases of choriocarcinoma(CCA) paraffin-embedded tissues were measured by terminal deoxy-nucleotidyl transferase-mediated dUTP-biotin nick end labeling(TUNEL).Results:In NP,CM,IM and CCA,the apoptosis index(AI) was 1.88%,2.59%,6.45% and 1.26% respectively with significant difference among them(F=7.020,P=0.000).There were significant difference between IM and CCA(P=0.009).Conclusion:The process of GTT is associated with trophoblastic cell overproliferation because the proliferation and apoptosis are out of control.更多还原