【摘要】 目的:观察雌激素在大鼠部分肝缺血再灌注损伤中的作用。方法:60只SD大鼠随机分为雌性组(F组)、雄性组(M组)、雌性卵巢切除组(O组)、雄性雌二醇组(E2组),每组15只,分别研究雌激素在大鼠部分肝缺血再灌注损伤中的作用,以血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(AKP)水平作为评定肝损伤的指标。结果:F组的ALT、AST、AKP水平明显低于M组及O组(P< 0．05);E2组的ALT、AST、AKP水平明显低于M组及O组(P<0．05)。结论:雌激素对大鼠部分肝缺血再灌注损伤具有明显的保护作用。更多还原

【Abstract】 Objective: To study the effects of estrogen on reduced-size liver ischemia reperfusion injury in rats. Methods: 60 SD rats were divided into female group (F group) , male group (M group) , ovariectomy group (O group) and estrogen group (E2 group) at random. All the rats were made reduced-size liver ischemia reperfusion rats model, and ALT, AST, AKP content in serum were applied to evaluate the hepatic function in ischemia reperfusion injury. Results: The ALT, AST, AKP content in serum of F group were obviously lower than that of M group and O group (P<0. 05). The ALT, AST, AKP content in serum of E2 group were obviously lower than that of. M group and O group (P<0. 05). Conclusions: Es- trogen has significant protection for liver in reduced-size liver ischemia reperfusion injury.更多还原