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半叶马尾藻多糖对HL-60细胞CD11b和CD11a表达的体外影响
Effects of seaweed polysaccharide from Sargassum confusum on the expression of CD11b and CD11a in HL-60 cell
【摘要】 目的探讨半叶马尾藻多糖对HL-60细胞CD11b、CD11 a表达的影响。方法MTT研究半叶马尾藻多糖对HL-60细胞体外增殖的影响,采用流式细胞术研究对CD11b、CD11 a表达的影响。结果半叶马尾藻多糖能增高CD11b、CD11 a的表达率,且作用随时间和浓度的增加而增强。结论半叶马尾藻多糖在体外可影响HL-60细胞CD11b、CD11 a的表达,提示其在抗肿瘤方面有一定的开发应用前景。
【Abstract】 Objective To explore the effect of seaweed polysaccharide from Sargassum confusum on the expression of CD11band CD11a in HL-60 cell.Method The MTT and FCM approaches were adopted.Result Seaweed polysaccharide can increase the expression of CD11b and CD11a in a dose-and time-dependent manner.Conslusion The seaweed polysaccharide can interfere with effect the expression of CD11b and CD11a in HL-60 cell,suggesting it can be used as an antileukemia drug.
- 【文献出处】 滨州医学院学报 ,Journal of Binzhou Medical College , 编辑部邮箱 ,2006年05期
- 【分类号】R285
- 【被引频次】3
- 【下载频次】90