【摘要】 目的探讨缬沙坦对高血压患者的降压效果及降尿酸、减轻蛋白尿的作用。方法93例高血压合并高尿酸血症患者随机分为缬沙坦组(n=47)和氨氯地平组(n=46)。缬沙坦组给于缬沙坦(代文)80 mg/d,氨氯地平组给予氨氯地平(络活喜)5 mg/d治疗,同时观察两组血压、血尿酸、24 h尿白蛋白排泄率的变化。2周后血压控制无效者予加倍剂量服用,用药4、8、12周继续观察上述指标。结果①缬沙坦降压平稳有效,与氨氯地平组比较无显著差异(P>0.05);加倍剂量服用降压效果更显著。②缬沙坦组血尿酸下降,24 h尿尿酸排泄增加,24 h尿蛋白排出减少,与氨氯地平组比较有显著差异(P<0.05)。结论缬沙坦能同时降压和降尿酸,减少尿蛋白,有很好的肾脏保护作用。更多还原

【Abstract】 Objective To study the efficacy of valsartan on blood pressure and plasma urine albumins in the patiennts with primaryhypertension.Methods 93 patients with primary hypertension accompanied by hyperuricemia were randomly divided into valsartangroup(n=47) and amlodipine group(n=46).The two groups were respectively given valsartan of 80mg/d and amlodipine of 5mg/din the first two weeks.The doses of the two drugs in the patients without effect were doubled from third week.The duration of the treat-ment was 12 weeks.We observed the blood pressure,uric acid and albumins in urine of 24 hours,electrolyte and so on in the end of 2,4,8,12 week.Results There is no significant difference between the two groups in reducing hypertension,but the effect of reducinghypertension was better after the doses were doubled.Compared with amlodipine,plasma uric acid and the excretion of albumin in 24hour urine is lower and uric acid in 24 hour urine is higher.There are obvious differences in all parameters above between the groups(P<0.05).Conclusion Valsartan has a good protective effect on the kidney in the same time of reducing hypertension,plasma uricacid,and proteinuria.更多还原