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鼠双微粒体2/p53通路与乳腺癌的研究进展
Advances in study ofmurine double minute 2/p53 passway with breast cancer
【Abstract】 Mutant or aberrant regulation of expressing products of p53 gene results in losing its tumor suppressive function,which is often seen in many malignancies,including breast cancer.Oncoprotein MDM2 plays a primary role in regulating P53,and these two form an automregulatory feed back loop.mdm 2/p53 pass way performs important function in development,progression,therapy and prognosis of breast cancer.Besides,more and more studies show that some other molecular markers in breast cancer,such as PI3K/Akt/mTOR, p14ARF, and Her2/neu can regulate this passway unneglectedly.The purposeof this reviewis to summarize not only the relations betweenmdm 2/p53 passway and pathological charac-ters,therapy and prognosis of breast cancer,but also the relations of this passway with some other molecular proteins in breast cancer.
【Key words】 Genes,p53; Breast neoplasms; Gene amplification; Gene expression;
- 【文献出处】 北京大学学报(医学版) ,Journal of Peking University(Health Sciences) , 编辑部邮箱 ,2006年05期
- 【分类号】R737.9
- 【被引频次】2
- 【下载频次】178