【摘要】 目的研究成年人急性白血病(AL)细胞非系列相关抗原和“裸细胞”型的表达特征及预后。方法选用22种单克隆抗体,采用间接免疫荧光的方法,对367例AL患者进行免疫分型。根据EGIL标准诊断“裸细胞”型。结果成年人非系列相关抗原表达和“裸细胞”型的发生率在急性髓系白血病(AML)中占6.78%,其中早期干/祖细胞表达阳性率为75%,明显高于同期非“裸细胞”型AL(P<0.05)。10例患者治疗后完全缓解率为40%,明显低于同期非“裸细胞”型AL(P<0.05)。结论呈“裸细胞”型表达的AL大多为AML,CR率低,合适的治疗方案有待于进一步探讨。更多还原

【Abstract】 Objective To study uncommon subtypes of unlineage-associated antigens and null cell expression characteristic of adult acute leukemia immunophenotype and prognosis.Methods 367 patients with AL were investigated with MoAb and indireat immunofluorescence."null cell" type was diagnosed according to EGIL scoring system.Results The incidence of unlineage-associated antigens expression and "null cell" type was 6.78 % in adult AML.The hematopoietic stem/progenitor were expressed in 75 % of the "null cell" type AL cases.In the 10 cases treated,the complete remission(CR)rate was 40 %,"null cell" tyes had significantly higher expression rates of hematopoietic stem/progenitor and Lower CR tate(P < 0.05;P < 0.05,respectively),compared with those of "non-null cell" type cases observed during the same period.Conclusion AL "null cell" type was related with AML,it had a lower CR rate.Appropriate chemotherapeutic strategy should be further searched.<更多还原