【摘要】 目的比较柔红霉素联合阿糖胞苷骨髓腔给药诱导缓解急性非淋巴细胞白血病(简称急非淋)的疗效和毒副反应。方法用随机对照的方法将40例初治急非淋患者分为骨髓腔给药组(A组,20例)和静脉给药组(B组,20例),观察两组的疗效和毒副反应。结果A组与B组完全缓解率分别为70%,35%。总有效率分别为85%,50%。两组比较,差异均有统计学意义(P<0.05)。两组心脏毒性、胃肠道反应发生率比较,差异有统计学意义(P<0.05)。两组骨髓抑制发生率比较,差异无统计学意义(P>0.05)。结论骨髓腔给药诱导缓解急非淋具有较好的治疗效果,毒副反应小。更多还原

【Abstract】 Objective To compare the efficacy and adverse effects of rubomycin plus cytarabine(DA) dripping in bone marrow with DA dripping in vein in the treatment of acute nonlyphocytic leukemia (ANLL). Methods 40 cases of previously untreated ANLL patients were randomly divided into two groups, group A(DA dripping in bone marrow) and group B (DA dripping in vein). the efficacy and adverse effects of both groups were compared. Results The complete remission (CR) rate was 70 % and 35 % in group A and group B, and the total response rate was 85 % and 50 %, respectively. Both were significant higher than those of group B (P <0.05). The toxic reaction of the heart was 15 % and 60 %, and gastrointestinal reaction rate was 25 % and 65 % in group A and group B, respectively. Both were significant lower than those of group B (P <0.05). Arrest of bone marrow rate was 50 % and 55 % in group A and group B, respectively. There was no significant lower than that of group B (P >0.05). Conclusion The treating outcome was better in group A than in group B for ANLL, with higher cure remission rate and lower toxic reaction.更多还原