【摘要】 目的探讨急性白血病(AL)患者治疗前后血浆血栓调节蛋白(TM)、蛋白C(PC)抗原、D-二聚体(D-D)含量变化及其临床价值。方法采用酶联免疫吸附检测(ELISA)方法检测22例AL患者治疗前后血浆TM,PC抗原,D-D含量的变化。结果AL患者化疗前血浆TM,D-D升高,PC抗原降低,与正常对照组比较差异有统计学意义(P<0.01)。缓解后,血浆TM,PC抗原均恢复至正常水平,血浆D-D含量比治疗前有明显降低(P<0.01),但仍高于正常水平(P<0.01)。结论AL患者存在不同程度的血管内皮细胞损伤、凝血及纤溶系统的激活,并随病情的好转而逐渐改善。更多还原

【Abstract】 Objective In order to study the levels of plasma thrombomodulin(TM), protein C(PC) antigen and D-Dimer(D-D) before and after treatment in acute leukemia , and to explore their clinical significance. Methods Twenty-two patients with acute leukemia were selected into the study, the levels of plasma thrombomodulin, protein C antigen and D-Dimer were measured by ELISA. Results Compared with normal control group, the plasma levels of TM and D-D were elevated and plasma PC antigen levels were reduced before treatment in acute leukemia patients (P <0.01). After complete remission, plasma levels of TM and PC antigen returned to normal range except for D-D compared with normal control group(P <0.01). Conclusion These results suggest that activation of coagulation and fibrinolysis existed in patients with acute leukemia as well as injury of vascular endothelium, and were greatly improved with amelioration of the disease.更多还原