【摘要】 目的:探讨血浆中神经肽Y(NPY)和神经降压素(NT)两者比例失调在原发性高血压(EH)发病中的作用。方法:采用放射免疫分析法(RLA)检测176例EH患者血浆中的NPY和NT水平,同时设正常对照组(n=84)。结果:EH患者血浆中的NPY水平明显高于对照组(P<0·01),并随病情加重而升高(P<0·01);NT水平明显低于对照组(P<0·01),并随病情的加重而下降(P<0·01);NPY/NT比值高于对照组(P<0·01),与病情相一致。结论:NPY、NT参与了高血压病的发病过程。NPY/NT比例失调可能是EH发病机制之一。更多还原

【Abstract】 Objective To study the effects of changes of neuropeptide Y(NPY) and neurotensin(NT) concentrations in plasma and their ratio imbalance on the incidence of essential hypertension (EH). Methods NPY and NT in plasma in 176 patients with EH were measured with radioimmunoassay(RIA). Results NPY in the EH patients was higher than that in the normal subjects (P<0.01), and went up with the aggravation of the patients′ condition( P<0.01).NT in the EH patients was lower compared with the normal subjects (P<0.01), and went down with the aggravation of the patients′ condition ( P<0.01). NPY/NT in the EH patients was higher than that in the normal subjects (P<0.01), and was accordant with patients′ condition. Conclusion NPY and NT are involved in the incidence of EH.The ratio imbalance of NPY/NT may be one of the factors causing EH.更多还原