【摘要】 采用薄膜超声法制备卵磷脂(EPC)和氢化卵磷脂(HEPC)长循环阿霉素脂质体,研究比较EPC和HEPC长循环阿霉素脂质体在大鼠体内释药的差异,选择良好的靶向性药物载体。用高效液相色谱法研究EPC和HEPC长循环阿霉素脂质体在大鼠体内的药物动力学。大鼠体内药物动力学研究结果表明,HEPC长循环阿霉素脂质体在血中平均驻留时间(MRT)为23.3h,EPC长循环阿霉素脂质体在血中MRT为12.0h。HEPC长循环阿霉素脂质体是更好的靶向性药物载体。更多还原

【Abstract】 To study the preparation and slow release of EPC and HEPC doxorubicin liposomes.choosing a better carrier in delivering the drugs.the pharmacokinetics of EPC and HEPC sterically stabilized liposomes(EPC-SSL,and HEPC-SSL)were studied by HPLC.studies on pharmacokinetics showed that the mean residence time(MRT)of HEPC-SSL in blood is 23.3h,while MRT of EPC-SSL is 12.0h,and the area under the curve(AUC)of concentration of HEPC-SSL is larger than that of EPC-SSL.Conclusion HEPC-SSL is a better carrier in delivering the drugs to the extravascular sites than EPC-SSL.更多还原