【摘要】 本文力图设计与合成在人体结肠厌氧菌存在环境下,可被微生物降解的生物材料。用三种亲疏水性不同、软硬段不同的三种单体,即甲基丙烯酸羟乙酯(HEMA)、甲基丙烯酸(MAA)、甲基丙烯酸甲酯(MMA)为载体,并用对甲基丙烯酰胺偶氮苯(BMAAB)为偶联剂,合成了聚甲基丙烯酸羟乙酯-甲基丙烯酸甲酯-甲基丙烯酸[P(HEMA-MMA-MAA)]三元偶氮聚合物。用红外、紫外、核磁共振进行化学结构表征,并测定了该材料的溶胀性能,比较了聚合物降解前后分子量、热性能与形态变化。结果证明材料的降解程度与材料中亲水组分含量直接相关。更多还原

【Abstract】 To design and synthsize the microbiogenic degradable biomaterials under the colonic environment in human body.The azocopolymer poly(HEMA-MMA-MAA) was synthesized using three kinds of monomers,2-hydroxyethylmethacrylate(HEMA),methylmethacrylate(MMA),and methacrylic acid(MAA),as comonomers azobisisobutyronitrile(AIBN) as initiator,cross-linked with Bis(methacryloylamino)-azobenzene(BMAAB).The chemical structure of azocopolymer was elucidated with UV.FTIR spectroscopy and nuclear magnetic resonance data.The swelling behavior was evaluated by the swelling equilibrium parameter Q.The biodegradation properties were assessed using Differential Scanning Calorimeters(DSC) and Gel Permeation Chromatography(GPC).The surface morphology of the material before and after degradation was observed by Scanning Electron Microscopy(SEM).The investigated results show that the degradation behavior of this azopolymer was relevant to the ratio of three components in the copolymers.更多还原