【摘要】 研究血清抵抗素与2型糖尿病(DM)患者胰岛素抵抗(IR)的关系。应用EIA测定72例2型DM患者(非肥胖2型DM组33例,肥胖2型DM组39例)及34名健康者(对照组)的空腹血清抵抗素水平。对照组、肥胖2型DM组及非肥胖2型DM组血清抵抗素水平分别为11.0±6.5μg/L、30.2±9.5μg/L及19.1±8.3μg/L,肥胖2型DM组和非肥胖2型DM组血清抵抗素水平均显著高于对照组(P均<0.001),肥胖2型DM组血清抵抗素水平显著高于非肥胖2型DM组(P<0.001),血清抵抗素水平与2型DM患者HOMAIR指数和程度呈显著正相关(P<0.001)。更多还原

【Abstract】 To investigate the relationship of serum resistin with insulin resistance in type 2 diabetic mellitus(DM) patients, the serum resistin level was measured by EIA in 72 type 2 DM and 34 normal subjects. The serum resistin levels were 11.0±6.5μg/L ,30.2±9.5μg/L and 19.1±8.3μg/L in normal subjects and type 2 DM patients with and without obesity respectively. The serum resistin levels were higher in type 2 DM patients either with or without obesity than in the normal subjects(P<0.001). The resistin levels in diabetic patients with obesity were higher than in patients without obesity(P<0.001). The serum resistin levels in type 2 DM patients were positively associated with HOMA-IR(P<0.001). Serum resistin levels were significantly related to the degree of insulin resistance in type 2 DM patients.更多还原