【摘要】 目的探讨二甲苯对正常人外周血淋巴细胞DNA的损伤作用。方法采用染色体分析技术,对体外培养的外周血淋巴细胞姊妹染色单体交换(SCE)频率进行观察。结果3.0、6.0 mmol/L二甲苯组淋巴细胞中的SCE计数平均值分别为7.533±0.234、10.933±0.325,与对照组(2.800±0.242)比较,差异具有极显著性(t=14.084、20.085,P<0.001)。结论二甲苯对正常人外周血淋巴细胞DNA有显著损伤作用。更多还原

【Abstract】 ObjectiveTo investigate the damage of xylene on DNA of human peripheral blood lymphocytes.Methods Chromosome analysis technique was used to study sister chromatid exchange(SCE) frequencies of in-vitro-culture blood lymphocyte.ResultsThe frequencies of SCE in xylene groups(3.0 mmol/ L,6.0 mmol/ L) were 7.533±0.234 and 10.933±0.325 respectively,which were significantly higher than that of the control group(2.800±0.242)(t=14.084,20.085;P<0.001).(ConclusionThe) injury of xylene to human peripheral blood lymphocytes is significant.更多还原