【摘要】 目的:为研究Perthes病治疗建立理想的动物模型。方法:采用健康未成年杂种犬20只,随机分为两组,一组每周肌肉注射甲基强的松龙(16 mg/kg)2次;另一组用液氮冷冻股骨头,术后定期行X线、MR、IECT检查,并取股骨头行组织切片了解股骨头坏死情况。结果:两实验组均出现股骨头缺血性坏死,激素组第4周复制成功率为40.0%,第8周成功率为75.0%,总成功率为55.6%;而液氮冷冻组第4周复制成功率为90.0%,第8周成功率为100.0%,总成功率95.0%。结论:单独使用激素或液氮冷冻股骨头均可建立幼犬股骨头坏死模型,但单用激素并非一定引起股骨头坏死。液氮冷冻建立的幼犬股骨头坏死可作为研究Perthes病治疗的理想动物模型。更多还原

【Abstract】 Objective:To establish the ideal animal model for the study of Perthes disease.Methods:Twenty healthy young dogs were randomily divided into two groups.Dogs in one group were injected into muscle with methylprednisolone twice a week for 2 moths.Dogs in other groups were frozen by liquid nitrogen.Xray,MRI,ECT and histology examination were made periodically after experiment to evaluate osteonecrosis.Results:Necrosis of the femoral head in 4th and 8th week was confirmed in two experiment groups.The success rates were 40.0% in 4th week and 75.0% in 8th week with the methylprednisolone group,while in the liquid nitrogen group,the success rates were 90.0% in 4th week and 100.0% in 8th week.Conclusions:The model of Perthes disease could be built up by steroid-injection or liquid nitrogen in young dogs,but not all the dogs model can be built by steroid-injection.The animal model of Perthes disease with liquid nitrogen in young dogs can be established.更多还原