【摘要】 链激酶(Streptok inase,SK)是世界上最早发现的纤维蛋白酶原激活剂,也是最早作为临床药品治疗血栓性疾病的溶栓酶。它是由A,C,G群链球菌中β-溶血性链球菌分泌的胞外非酶蛋白质,能和纤溶酶原结合,将纤溶酶原激活为纤溶酶,具有溶解血栓的作用。本文详细综述了该酶的性质、在溶栓酶中的地位、研究历史、作用机理等。此外,由于它有半衰期短、不具有纤维蛋白特异性、治疗后出血和血栓易复发的缺点,所以有必要用基因工程的手段进行改造,以达到更好的治疗效果。更多还原

【Abstract】 Streptokinase(SK) was discovered as the first plasminogen activator in the world,and it was the earliest clinical agent to cure thrombus.Streptokinase is an extracellular protein which is produced by β-hemolytic streptococci group A,C and G.It binds to plasminogen(Pg) to form a complex that converts substrate Pg to plasmin.And it can lyse blood clots.We summarized the characteristics、status、research history、catalytic mechanism of it.In addition,Because of its short half-life、bleeding、non fibrin-specific and recurring rate,it is necessary to reconstruct it by gene engineering to obtain better curative effect.更多还原