【摘要】 背景与目的:目前国内外有关结肠癌根治术后复发转移的预后报道尚不多,且研究结果不一。本研究旨在探讨结肠癌患者根治术后复发转移的相关临床病理因素。方法:选择1999年1月至2000年12月在中山大学肿瘤医院行结肠癌根治术患者152例,Cox模型分析临床病理因素与复发转移的关系。结果:全组复发转移率为19.74%,肝转移率为9.87%。单因素分析显示,有无输血、病程、肿瘤大小、肿块活动度、分化程度、Dukes@分期、淋巴结转移与结肠癌术后复发转移有关,有无输血、术前血清CEA水平、肿块活动度、分化程度、Dukes@分期、淋巴结转移与术后肝转移有关;多因素分析显示,肿块活动度、分化程度、淋巴结转移与结肠癌术后复发转移有关,术前血清CEA水平、分化程度、淋巴结转移与术后肝转移有关。结论:肿块活动度、分化程度和淋巴结转移是影响结肠癌患者根治术后复发转移的重要预后因素,术前血清CEA升高、肿瘤分化不良、淋巴结转移的患者术后肝转移的风险增大。更多还原

【Abstract】 BACKGROUND & OBJECTIVE: The prognosis of colon cancer after radical resection has seldom been reported, and the results are different. This study aimed to investigate the clinicopathologic factors related to recurrence and metastasis of colon cancer after radical resection. METHODS: The clinicopathologic and follow-up data of 152 patients with colon cancer, treated with radical resection from Jan. 1999 to Dec. 2000, were analyzed retrospectively. RESULTS: The overall recurrence and metastasis rate was 19.74%, and the liver metastasis rate was 9.87%. Univariate analysis showed that blood transfusion, disease duration, tumor size, tumor movement, histological differentiation, Dukes’ stage, and lymph node involvement were correlated to recurrence and metastasis of colon cancer after operation; blood transfusion, serum concentration of carcinoembryonic antigen (CEA), tumor movement, histological differentiation, Dukes’ stage, and lymph node involvement were correlated to liver metastasis. Multivariate analysis showed that tumor movement, histological differentiation, and lymph node involvement were prognostic factors for recurrence and metastasis, while serum concentration of CEA, histological differentiation, and lymph node involvement were prognostic factors for liver metastasis. CONCLUSIONS: Tumor movement, histological differentiation, and lymph node involvement are important prognostic factors for recurrence and metastasis of colon cancer after radical resection. Patients with high serum concentration of CEA, poor histological differentiation, and lymph node involvement have increased risk of liver metastasis.更多还原