【摘要】 背景与目的:近20年来,鼻咽癌高发区广东省大样本的流行病学调查研究较少,为了在一定程度上反映近年来该高发区鼻咽癌的发病特点,本研究以住院患者的病例资料为基础,总结了一批近年来广东籍鼻咽癌患者的临床资料,为更准确反映广东高发区鼻咽癌的发病规律提供资料及制定防治措施提供依据。方法:收集1998年1月至2000年8月在中山大学肿瘤防治中心住院治疗的全部广东籍初诊鼻咽癌患者共1142例的病例资料。按照事先制定的调查表,收集患者的临床资料并进行统计分析。结果:在广东籍患者中,鼻咽癌的发病具有明显的家族聚集性,21.9%的患者具有肿瘤家族史,12.3%的患者有鼻咽癌家族史,并且,鼻咽癌越高发的地区其家族聚集性越明显;VCA/IgA的抗体阳性率为90.0%,EA/IgA的抗体阳性率为74.5%,抗体滴度与肿瘤负荷呈正相关;鼻咽癌的早诊率在30%左右。结论:广东籍鼻咽癌患者的发病特点是具有明显的家族聚集性、区域聚集性;VCA/IgA、EA/IgA抗体阳性率高,有助于早期诊断。更多还原

【Abstract】 BACKGROUND & OBJECTIVE: Few large-scale epidemiologic investigations of nasopharyngeal carcinoma (NPC) at high incidence region in Guangdong province were reported in recent 20 years. This study was to summarize clinical data of a population of hospitalized Cantonese NPC patients, analyze the epidemiologic characteristics of NPC in the high incidence region, and provide references for the prevention and treatment of NPC. METHODS: Clinical data of 1 142 Cantonese NPC patients, hospitalized in Cancer Center of Sun Yat-sen University between Jan. 1998 and Aug. 2000, were collected according to well-designed forms and statistically analyzed. RESULTS: The morbidity of NPC in Cantonese showed obvious family clustering: 21.9% of the patients had family history of cancer, and 12.3% had family history of NPC. Moreover, the family clustering feature was more obvious in the population from the region with higher incidence of NPC. The positive rate of VCA/IgA antibody was 90.0%, and that of EA/IgA antibody was 74.5% ; the titers were positively related to tumor burden. Early diagnostic rate of NPC was about 30%. CONCLUSIONS: NPC patients in Cantonese population have obvious family and territorial clustering. High positive rates of VCA/IgA and EA/IgA antibodies are helpful for early diagnosis of NPC.更多还原