【摘要】 基因治疗已在治疗多种人类重大疾病如遗传病、肿瘤等方面显示出良好的应用前景,但也面临着巨大的挑战,主要是如何选择安全、高效、靶向的载体系统。基因治疗的靶向性研究近年来取得了许多新的进展,如应用重组病毒载体,借助抗体或配体将治疗基因定向导入靶细胞。纳米生物材料由于其良好的生物安全性,可方便有效地实现基因的靶向性及高效表达,成为制备高效、靶向的基因治疗载体系统的良好介质,在基因治疗载体系统中日益受到广泛重视。本文综述了目前国内外在靶向基因转移系统中的最新研究进展。更多还原

【Abstract】 Gene therapy has shown great potentials in the treatment of a number of human key diseases,such as genetic diseases,cancer and so on,yet there are still some big challenges to face.One of these challenges is how to develope efficient,safe,targeting and controlled release gene delivery systems.In recent years the research on targeting in gene therapy has made much exciting progress.The using of the rebuilding virus vectors,many new technologies also show great promising prospects such as the delivery of therapeutic gene to targeted cells by some antibodies or ligands.Nanobiomaterials have great potenticies in developing the ideal gene transfer vector just because of their properties of bio-compatibility,bio-degradation,controllable release,easy modification for targeting and so on.In this paper,the latest progress of target gene delivery systems in-and-out was reviewed.更多还原