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奈福泮复合曲马多在剖宫产术后镇痛中的平衡应用

Nefopan combined with tramadol used for postoperative analgesia in patients with cesarean section

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【作者】 汪洪

【Author】 WANG Hong(Department of Anesthsiology,Wuhu First People’s Hospital,Wuhu,Anhui Province 241000)

【机构】 安徽省芜湖市第一人民医院麻醉科 安徽芜湖241000

【摘要】 目的观察静脉给予奈福泮和/或曲马多在剖宫产手术后镇痛的临床效果及不良反应。方法ASA I~II级120例剖宫产手术病人,随机分为奈福泮组(N组)和曲马多组(T组),每组60例,N组奈福泮20 mg+曲马多500 mg+恩丹西酮4 mg;T组曲马多700 mg+恩丹西酮4 mg,均用生理盐水稀释至100 m l。手术结束前5 m in给予负荷剂量后接镇痛泵,进行持续静脉镇痛(C IA)。分别于术后2、8、12、24、32 h采用视觉模拟评分法(VAS)及Ram say镇静评分法(RSS)对镇痛镇静效果进行评定,统计不良反应发生情况。结果VAS和RSS评分组间比较差异无显著性(P>0.05),但不良反应发生率T组明显高于N组。结论奈福泮与曲马多联合用于剖宫产手术的术后镇痛,虽效果与单独使用曲马多相当,但镇痛期间的不良反应发生率明显降低,二种药物联合应用显得更为安全。

【Abstract】 Aim To study the balance analgesia efficacy and side effects of nefopan and tramadol after cesarean section.Methods 120ASA I~II patients were randomly divided into two groups,nefopan group(group N) and tramadol group(group T).The patients in group N(n=60)were received nefopan 20 mg+tramadol 500 mg+ondansetron 4 mg and the patients in group T(n=60)received tramadol 700 mg+ondansetron 4 mg by continuous intravenous analgesia(CIA) after cesarean section.The visual analgesia scale(VAS) and Ramsay sedation Scale(RSS) were used to respectively assess the effects of analgesia and sedation at 2,8,12,24,32 hours after infusion of drugs.Side effects such as dizziness,nausea and vomitting were observed at the same time.Results There were no significant differences in VAS and RSS between two groups(P>0.05).But side effects were significantly increased in group N compared with those in group T(P<0.05).Conclusion The analgesia efficacy of nefopan combined with tramadol was as good as tramadol after cesarean section,but side effects were significantly increased in group T.Group N was safer than group T.

【关键词】 奈福泮曲马多平衡镇痛剖宫产术
【Key words】 nefopantramadolbalancecesarean section
  • 【文献出处】 安徽医药 ,Anhui Medical and Pharmaceutical Journal , 编辑部邮箱 ,2006年09期
  • 【分类号】R614;R719.8
  • 【被引频次】1
  • 【下载频次】34
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