【摘要】 目的建立同时测定复方氯唑沙宗胶囊中两种成分血药浓度的方法,并进行其在健康人体药物动力学研究。方法20名男性健康志愿者单剂量口服复方氯唑沙宗胶囊2粒,高效液相色谱法同时测定复方氯唑沙宗中氯唑沙宗和对乙酰氨基酚的血药浓度。结果和结论复方氯唑沙宗胶囊中的氯唑沙宗和对乙酰氨基酚主要药物动力学参数分别为:t1/21.629±2.218 h和3.82±1.222 h;Tm ax1.333±0.636 h和0.958±0.724 h;Cm ax4.995±2.11 mg.L-1和1.85±0.409 mg.L-1;AUC0~15 h12.16±4.192 mg.h-1.L-1和8.661±2.844 mg.h-1.L-1;AUC0~∞12.34±4.328和9.927±3.644 mg.h-1.L-1。更多还原

【Abstract】 Aim To investigate the pharmacokinetics of complex chlorzoxazone capsules in healthy volunteers.Method 20 male healthy subjects received a single dose of two pieces of complex chlorzoxazone capsules.The concentration of complex chlorzoxazone was determined by HPLC.Results and Conclusion The main pharmacokinetic parameters of chlorzoxazone and acetaminophen of complex chlorzoxazone capsules were as follows: t_1/2 1.629±2.218 h and 3.82±1.222 h;T_max1.333±0.636 h and 0.958±0.724 h;C_max4.995±2.11 mg·L^-1 and 1.85±0.409 mg·L^-1;AUC_{0¹5 h}12.16±4.192 mg·h^-1·L^-1 and 8.661±2.844 mg·h^-1·L^-1;AUC_0^∞12.34±4.328 and 9.927±3.644 mg·h^-1·L^-1.更多还原