【摘要】 目的考察甲磺酸培氟沙星注射液与维生素C注射液、维生素B6注射液、注射用辅酶A、硫酸庆大霉素注射液4种常用药物在5%葡萄糖溶液中配伍的稳定性。方法在室温下(25±1)℃放置2 h,观察甲磺酸培氟沙星注射液配伍后,其外观性状、pH值的变化,同时以高效液相色谱法测定甲磺酸培氟沙星的含量和有关物质变化。结果甲磺酸培氟沙星注射液与维生素B6注射液配伍2 h后,含量下降5.6%,而与其它几种药物配伍除有关物质略有增加外其余各项考察指标均较稳定。结论甲磺酸培氟沙星可与维生素C注射液、注射用辅酶A、硫酸庆大霉素注射液3种药物配伍使用,但建议与维生素B6注射液配伍使用时在1 h内使用完。更多还原

【Abstract】 Aim To study the compatibility of pefloxacin nesylate injection mixed with penicline for injection etc.in 5% GS infusion.Method The apperance,PH,and concentration of pefloxacin nesylate and the compounds of the related pefloxacin nesylate by HPLC were examined at 25℃ during 2 hours.Result The concentration of pefloxacin nesylate reduced by 5.6% in vitamine B₆injection.There was few change in other solutions.Conclusion The solution were stable at 25℃ for 2 hours when combined with vitamine C injection,coenzyme A for Injection,getamine injection,while that combined with vitamine B₆ injection are suggested to be used within an hour.更多还原