【摘要】 目的 :观察中药颗粒分煎与合煎是否存在疗效、药效不同差异。方法 :采用自拟复方健胃舒颗粒治疗脾虚肝郁型功能性消化不良患者 10 0例 ,分为分煎组与合煎组各 5 0例 ,对比观察两组临床疗效及药效。结果 :两组临床治愈率分别为 72 %和 70 % ,总有效率均为 96 % ,差异无显著性 (P >0 0 5 ) ;并且两组在抑制大鼠胃酸、胃蛋白酶活性 ,调节小鼠胃功能 ,促进小肠推进度及镇痛药理实验中差异无显著性 (P >0 0 5 )。结论 :健胃舒颗粒分煎与合煎疗效、药效保持一致 ,从一个侧面为单味中药浓缩颗粒在临床辨证施治中 ,灵活配方及加减应用 ,提供科学依据更多还原

【Abstract】 Objective: To observe the difference in therapeutic effect of Chinese herbal granule decocted separately and mingly. Methods: One hundred patients of functional dyspepsia of Spleen deficiency and Liver stagnancy type were treated with Jianweishu Granule (JWSG, a self formulated recipe by the author). Half of the patients received JWSG decocted separately, half of them received that decocted mingly. The therapeutic effects between the two groups were compared. Experimental observation on the effects of differently decocted remedies in rats was also conducted. Results: The therapeutic effects obtained in the two groups were similar, with respective cure rate of 72% and 70% and the total effective rate 96% in both group. There was insignificant difference between the two groups (P>0 05). Experimental study all showed no difference between the differently decocted remedies in inhibiting gastric acid, pepsin activity, gastric function regulation, small intestine movement improvement and pain alleviation in rats. Conclusion: The therapeutic effects of JWSG decocted separately or mingly are the same. This fact provides a scientific basis for clinical use of granule form of single Chinese herbs.更多还原