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健骨颗粒对去卵巢大鼠骨质疏松症预防作用的研究

Study on Preventive Effect of Jiangu Granule on Osteoporosis in Ovariectomized Rats

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【作者】 林燕萍马建华冯尔宥黄美雅

【Author】 LIN Yan ping, MA Jian hua, FENG Er you, et al Faculty of Orthopedics and Traumatology, Fujian College of TCM, Fuzhou (350003)

【机构】 福建中医学院骨伤系福建中医学院骨伤系 福州350003福州350003福州350003

【摘要】 目的 :探讨健骨颗粒对实验性Ⅰ型原发性骨质疏松症的预防作用。方法 :运用切除大鼠卵巢方法建立去卵巢骨质疏松症模型 ,采用双能X线骨密度测定法和放射免疫分析法等 ,检测实验鼠骨骼密度、血清骨钙素、雌二醇、降钙素水平以及子宫指数。结果 :健骨颗粒可明显升高骨密度和子宫指数 ,提高血清雌二醇、降钙素水平 ,降低骨钙素含量。结论 :健骨颗粒可通过调节机体相关内分泌功能 ,有效协调钙调节激素 ,降低骨的转换率 ,增加骨密度 ,对Ⅰ型原发性骨质疏松有预防或延缓发生的作用。

【Abstract】 Objective: To investigate the preventive effect of Jiangu granule (JGG) on experimental primary osteoporosis type Ⅰ. Methods: Osteoporosis model was established through ovary resection of female rats. Bone mineral density (BMD) was measured with double energy X ray absorptiometry. Level of endocrine markers, including osteocalcin (BGP), estradiol (E 2) and calcitonin (CT) in serum were examined by RIA. And uterus parameters was calculated also. Results: JGG could significantly increase BMD and uterus index, improve the levels of E 2 and CT in serum, at the same time reduce the BGP level. Conclusion: JGG can efficiently prevent type Ⅰ primary osteoporosis or delay its occurrence by enhancing the function of endocrine system, coordinating the action of calcium related hormone, reducing bone turnover rate and increasing BMD.

【基金】 福建省自然科学基金重大项目 (No .C9830 0 0 1 ) ;教育部骨干教师资助计划项目 (No.1 946)
  • 【文献出处】 中国中西医结合杂志 ,Chinese Journal of Integrated Traditional and Western Medicine , 编辑部邮箱 ,2002年05期
  • 【分类号】R285
  • 【被引频次】32
  • 【下载频次】93
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