【摘要】 为探讨劳损愈贴膜的抗炎镇痛活血作用 ,分别取健康昆明种小鼠和 Wistar大鼠随机均分为 4组 ,即赋形剂对照组、阳性对照组和劳损愈贴膜高、低剂量组 ,分别外用 30 %乙醇、麝香壮骨止痛膏、劳损愈贴膜高剂量 (每公斤含生药 15 .5 0 g)、低剂量 (每公斤含生药 7.75 g)。采用了小鼠二甲苯耳廓肿胀法、大鼠足跖蛋清肿胀法、小鼠醋酸扭体法、小鼠热板法、小鼠腹腔血瘀证模型羊红细胞测定法等进行实验观察。结果显示 ,劳损愈贴膜高剂量对小鼠耳廓二甲苯所致肿胀具有明显抑制作用 ;高、低剂量均对蛋清诱导的大鼠足跖炎症具有较好的抑制作用 ,对醋酸诱导的小鼠扭体反应为指标的疼痛具有明显抑制作用 ,对热板法致痛具有明显抑制作用 ;可明显促进血瘀证模型体内羊红细胞的吸收 ,具有良好的活血化瘀作用。表明劳损愈贴膜具有良好的抗炎镇痛和活血化瘀作用更多还原

【Abstract】 To explore the anti-inflammatory, analgesia and promoting blood circulation effect of "Laosunyutiemo"(LSYTM) the healthy Kunming mice and Whistar rats were divided into 4 groups in random: excipient contrast group, positive contrast group, LSYTM low dosage group, LSYTM high dosage group, and were treated respectively with 30% alcohol, "Zhuanggushexiangzhitonggao", LSYTM high dosage(15.50g·kg -1 crude drug), LSYTM low dosage group(7.75g·kg -1 crude drug). Mouse ear edema induced by xylene, rat plantar edema induced by albumin, mouse pain threshold induced by hot plate, mouse body twisting reactions induced by acetic acid and sheep red blood cell assay of mouse celiac blood stasis were used. The results showed that high dosage LSYTM had obvious inhibitory effect to rat plantar edema induced albumin, high and low dosage LSYTM had the better inhibitory effect to the rat plantar induced by albumin, the ache of mouse pain threshold induced by hot plate and mouse body-twisting reactions induced by acetic acid, and can obviously promote the absorb of sheep red blood cell in celiac blood stasis model. It was suggested that LSYTM has better anti inflammatory, analgesic effect and can promote blood circulation to remove blood stasis更多还原