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脾虚大鼠经胃泌素刺激胃酸分泌的敏感性及补中益气汤的作用

Effect of Buzhong Yiqi Tang (补中益气汤) on the hypersensitivity of gastric acid secretion stimulated by gastrin in rat with deficiency of the Pi

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【作者】 许琦巫燕莉王建华王汝俊

【Author】 Xu Qi, Wu Yanli, Wang Jianhua, Wang Rujun (Piwei Institute, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405)

【机构】 广州中医药大学脾胃研究所广州中医药大学脾胃研究所 广州510405广州510405广州510405

【摘要】 目的 :研究“脾虚”大鼠经胃泌素刺激后胃酸分泌的敏感性及补中益气汤的作用。方法 :观察了正常、大黄“脾虚”模型、“脾虚”后经补中益气汤治疗三组动物在未经刺激及经胃泌素刺激后的胃液总酸度变化。结果 :未经刺激时三组动物的胃液总酸度无显著差异 ;“脾虚”大鼠经刺激后显著升高 ,补中益气汤对其有复健作用。结论 :补中益气汤能降低“脾虚”大鼠经胃泌素刺激后胃酸分泌的敏感性。

【Abstract】 Objective: To study the effect of Buzhong Yiqi Tang (BYT) on the hypersensitivity of gastric acid secretion stimulated by gastrin in rats with deficiency of the Pi. Methods: Observe the gastric acid secretion without stimulated or stimulated by gastrin in normal rats, rats with deficiency of the Pi, and which treated by BYT. Results: Without stimulation, there is no difference between these rats; however, after stimulation significantly increase the hypersensitivity of gastric acid secretion in rats with deficiency of the Pi was observed. After treated by BYT the condition reversed. Conclusion: BYT can decline the hypersensitivity of gastric acid secretion stimulated by gastrin in rats with deficiency of the Pi.

  • 【文献出处】 中药药理与临床 ,Pharmacology and Clinics of Chinese Materia Medica , 编辑部邮箱 ,2002年05期
  • 【分类号】R228
  • 【被引频次】15
  • 【下载频次】191
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