【摘要】 目的研究参熊心痛丸对心脏血流动力学的影响。方法犬十二指肠给予不同剂量参熊心痛丸后,测定心脏血流动力学参数。结果给予参熊心痛丸2g/kg后,冠脉流量明显增加,冠脉阻力降低,心率减慢,降低左室舒张末期压;对左室收缩性能、左室做功及心脏泵血功能无明显影响。结论参熊心痛丸缓解心绞痛的作用是通过扩张冠脉,增加冠脉血流量,从而增加氧的供应,而主要不是通过减少氧的消耗来实现的。更多还原

【Abstract】 Objective: To study the effect of Shenxiong Xintong Pill(SXP) on cardiac hemodynamics. Methods: Parameters of cardiac hemodynamics were examined in anesthetic chest-opened dogs medicated with various doses of SXP. Results: After intraduodenal administration of SXP of 2.0g/kg, the coronary blood flow was raised, coronary resistance decreased, heart rate slowed and the left ventricular diastolic end pressure fallen in the dogs. No obvious changes were found in the contraction , works and ejection of left ventricle. Conclusion: The mechanism of SXP in relieving angina pectoris was probably related to the dilatation of coronary artery and increase of coronary flow with the increase supply of oxygen.更多还原