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青心酮三种给药途径的生物利用度比较研究
Comparison of Bioavailability of Qingxintong by Three Administration Routes
【摘要】 以 3种给药途径在恒河猴体内进行青心酮生物利用度比较。实验结果表明 :青心酮在动物体内具有吸收快 ,消除快的特点 ,肌肉注射与灌胃给药的吸收半衰期在 0 .0 5~ 0 .0 7h之间 ,消除半衰期在 0 .14~ 0 .2 9h之间。肌肉给药 10mg/kg的剂量与静脉给药相同剂量的相对生物利用度为 94 .71%。灌胃给药 6 0mg/kg剂量与静脉给药 10mg/kg的剂量相对生物利用度仅为 9.16 %。
【Abstract】 The in-vivo bioavailability of Qingxintong administrated by intramuscular injection, intravenous injection and gastric infusion was compared. Experimental results showed that Qingxintong was rapidly absorbed and excreted. The half-life time for absorption was 0.05 - 0.07 h and the half-life time for elimination was 0.14 - 0.29 h. The bioavailability of Qingxintong in the dose of 10 mg/kg by intramuscular injection or by intravenous injection was 94.71 %, and was 9.16% in the dose of 60 mg/kg by gastric infusion or in the dose of 10mg/kg by intramuscular injection.
【Key words】 Qingxintong/pharmacokinetics; @Qingxintong/analysis; Chromatography,high pressure liquid;
- 【文献出处】 中药新药与临床药理 ,Traditional Chinese Drug Research & Clinical Pharmacology , 编辑部邮箱 ,2002年01期
- 【分类号】R285.5
- 【被引频次】2
- 【下载频次】78